COMT

Basic Information

Gene Symbol	COMT
Entrez Id	1312
Position	chr22:19929263..19957498
Description	catechol-O-methyltransferase
Gene type	protein-coding

SNP Information

SNP	Position	Alelle	Gene	Annotation	Info	Or	Se	P-value	eQTL	Score^*
rs1109436	22:19953882	T/C	COMT	intron,near-gene-3	0.972	0.98847	0.0147	0.4327		4
rs111450487	22:19945817	A/G	COMT	intron	0.720	0.97006	0.0617	0.6228		6
rs112080665	22:19938759	A/G	COMT	intron,near-gene-5	0.932	1.00541	0.0259	0.8338		7
rs113099378	22:19938617	T/G	COMT	intron,near-gene-5	0.769	1.02378	0.0154	0.1262		7
rs113208324	22:19944496	T/C	COMT	intron	0.870	0.99332	0.0170	0.6922		6
rs117222687	22:19956014	C/G	COMT	intron	0.810	1.00582	0.0242	0.8091		4
rs11912353	22:19947341	A/G	COMT	intron	0.746	1.02347	0.0130	0.07488		2b
rs11912354	22:19947347	C/G	COMT	intron	0.737	1.02984	0.0128	0.02165		4
rs12053782	22:19932095	T/C	COMT	intron	0.997	1.01430	0.0118	0.2282		6
rs13054814	22:19943895	T/C	COMT	intron	0.846	1.00371	0.0175	0.833		6
rs13055002	22:19955961	T/C	COMT	intron	0.704	1.03241	0.0517	0.5377		4
rs138433986	22:19947346	A/G	COMT	intron	0.734	1.03035	0.0128	0.01891		-
rs141796830	22:19934554	A/T	COMT	intron	0.933	1.03138	0.0472	0.5129		-
rs143083716	22:19939918	A/T	COMT	intron	0.920	0.97356	0.0345	0.4367		-
rs148667152	22:19955220	T/C	COMT	intron	0.758	1.17492	0.0720	0.02522		-
rs148742700	22:19938611	A/G	COMT	intron,near-gene-5	0.769	1.03717	0.0449	0.4168		-
rs149813069	22:19938835	T/C	COMT	intron,near-gene-5	0.914	0.97229	0.0475	0.5537		-
rs151284584	22:19955349	T/C	COMT	intron	0.759	1.17457	0.0719	0.0253		-
rs1544325	22:19931668	A/G	COMT	intron	1.000	0.99402	0.0106	0.5752		4
rs165599	22:19956781	A/G	COMT	intron,near-gene-3,untranslated-3	0.989	1.01207	0.0114	0.29		4
rs165722	22:19949013	T/C	COMT	intron,near-gene-5	0.990	0.99273	0.0106	0.4897		4
rs165728	22:19957023	T/C	COMT	intron,near-gene-3,untranslated-3	0.988	1.03417	0.0211	0.1123		4
rs165879	22:19941004	A/G	COMT	intron	0.934	0.97326	0.0224	0.2261		5
rs165895	22:19953059	T/C	COMT	intron	0.843	1.02102	0.0122	0.08746		7
rs16982844	22:19947942	A/C	COMT	intron	0.789	0.99880	0.0262	0.964		3a
rs174674	22:19934025	A/G	COMT	intron	0.994	0.99293	0.0116	0.5382		6
rs174675	22:19934051	T/C	COMT	intron	0.994	0.99352	0.0116	0.5728		7
rs174680	22:19934999	T/C	COMT	intron	0.987	0.99422	0.0116	0.6202		5
rs174682	22:19935607	T/G	COMT	intron	0.996	0.99173	0.0107	0.436		2b
rs174685	22:19936308	T/C	COMT	intron	0.958	1.02316	0.0213	0.282		5
rs174686	22:19938710	A/T	COMT	intron,near-gene-5	0.831	0.96590	0.0189	0.06597		6
rs174687	22:19938837	A/G	COMT	intron,near-gene-5	0.940	0.97492	0.0216	0.2393		6
rs174688	22:19938880	T/C	COMT	intron,near-gene-5	0.671	1.01796	0.0132	0.1786		5
rs174689	22:19939353	A/G	COMT	intron	0.949	0.97142	0.0222	0.1913		4
rs174690	22:19939432	A/G	COMT	intron	0.941	0.99591	0.0110	0.7085		3a
rs174692	22:19940027	C/G	COMT	intron	0.907	0.99850	0.0111	0.8946		7
rs174697	22:19953832	A/G	COMT	intron,near-gene-3	0.971	0.96551	0.0214	0.1016		2b
rs174698	22:19954306	T/C	COMT	intron,untranslated-3	0.812	1.09243	0.0595	0.1373		7
rs174699	22:19954458	T/C	COMT	intron,untranslated-3	0.987	1.02953	0.0209	0.1629		5
rs188875826	22:19944722	T/C	COMT	intron	0.848	0.99114	0.0171	0.6027		-
rs3087869	22:19941507	A/G	COMT	intron	0.914	0.98768	0.0110	0.2631		3a
rs34068292	22:19952224	T/C	COMT	intron	0.954	1.05580	0.0274	0.04698		5
rs34300220	22:19942644	T/C	COMT	intron	0.770	0.93491	0.0576	0.2419		6
rs34798238	22:19932213	T/C	COMT	intron	0.974	1.00441	0.0140	0.7541		7
rs35478083	22:19956885	T/C	COMT	intron,near-gene-3,untranslated-3	0.953	1.02357	0.0270	0.3875		4
rs35788262	22:19940583	A/G	COMT	intron	0.896	0.99124	0.0168	0.6002		5
rs36082074	22:19956863	A/G	COMT	intron,near-gene-3,untranslated-3	0.638	0.98511	0.0405	0.7113		4
rs3788319	22:19929551	A/G	COMT	intron,near-gene-5	0.987	0.98373	0.0106	0.1219		3a
rs3819619	22:19941495	A/G	COMT	intron	0.903	0.98975	0.0146	0.4798		2b
rs3819621	22:19942176	A/T	COMT	intron	0.863	1.00491	0.0175	0.779		6
rs45454096	22:19929519	A/G	COMT	intron,near-gene-5	0.984	1.00321	0.0278	0.9069		4
rs45616631	22:19930810	T/C	COMT	intron,near-gene-5	0.983	0.99710	0.0278	0.9165		2b
rs4646312	22:19948337	T/C	COMT	intron,near-gene-5	0.991	0.97853	0.0108	0.04469		5
rs4646315	22:19951897	C/G	COMT	intron	0.890	0.98906	0.0145	0.4492		5
rs4646316	22:19952132	T/C	COMT	intron	0.992	1.01816	0.0123	0.1456		5
rs4646317	22:19952168	A/G	COMT	intron	0.989	1.02061	0.0108	0.05825		5
rs4646318	22:19954847	A/G	COMT	intron	0.923	0.96117	0.0253	0.118		5
rs5844401	22:19930187	I2/D	COMT	intron,near-gene-5	0.959	0.98452	0.0154	0.3104		-
rs5992499	22:19941774	T/G	COMT	intron	0.921	1.01106	0.0110	0.3188		4
rs5993879	22:19933411	A/C	COMT	intron	0.973	1.01704	0.0121	0.1605		7
rs6518593	22:19931853	T/C	COMT	intron	1.000	1.00562	0.0106	0.5984		7
rs66578812	22:19943643	I2/D	COMT	intron	0.878	1.00894	0.0113	0.4322		-
rs71312727	22:19945327	C/G	COMT	intron	0.877	0.98827	0.0163	0.4678		4
rs7287550	22:19931976	T/C	COMT	intron	0.994	1.00662	0.0116	0.5701		7
rs7290221	22:19942680	C/G	COMT	intron	0.916	0.98896	0.0110	0.3135		7
rs7291003	22:19931932	A/G	COMT	intron	0.986	1.00321	0.0138	0.816		7
rs737864	22:19930159	T/C	COMT	intron,near-gene-5	0.997	1.01623	0.0118	0.1722		4
rs73880029	22:19947773	T/C	COMT	intron	0.937	0.94308	0.0282	0.03772		5
rs74451762	22:19941703	T/C	COMT	intron	0.766	0.99223	0.0254	0.7596		4
rs76157168	22:19938709	T/C	COMT	intron,near-gene-5	0.880	1.01238	0.0126	0.3296		7
rs77080003	22:19944323	A/G	COMT	intron	0.914	0.96532	0.0342	0.3014		7
rs8185002	22:19933048	T/G	COMT	intron	0.997	0.98560	0.0118	0.2181		6
rs9306231	22:19930002	C/G	COMT	intron,near-gene-5	0.992	0.99690	0.0127	0.8043		2b
rs9306234	22:19953188	A/C	COMT	intron	0.948	0.98138	0.0110	0.08783		6
rs9306235	22:19955157	A/G	COMT	intron	0.904	1.03376	0.0217	0.1268		5
rs9332316	22:19930274	T/C	COMT	intron,near-gene-5	0.800	1.03241	0.0480	0.5054		4
rs9332325	22:19933687	T/C	COMT	intron	0.994	0.99352	0.0116	0.5779		4
rs9332332	22:19935071	A/G	COMT	intron	0.992	1.01521	0.0118	0.2014		5
rs9332334	22:19935148	T/C	COMT	intron	0.960	0.99910	0.0263	0.9719		5
rs9332342	22:19935643	T/C	COMT	intron	0.975	0.99312	0.0139	0.6215		2b
rs9332346	22:19942206	A/C	COMT	intron	0.873	0.99611	0.0168	0.8171		6
rs9332347	22:19942484	T/C	COMT	intron	0.865	0.99501	0.0170	0.7676		5
rs9332362	22:19949103	A/G	COMT	intron,near-gene-5	0.953	0.94620	0.0327	0.09086		5
rs9332370	22:19953899	T/C	COMT	intron,near-gene-3	0.931	0.97404	0.0273	0.3356		4
rs9332377	22:19955692	T/C	COMT	intron	0.980	1.01613	0.0148	0.281		4
rs9332381	22:19956553	C/G	COMT	intron,near-gene-3,untranslated-3	0.950	1.02840	0.0267	0.2949		5
rs9605040	22:19939900	T/C	COMT	intron	0.747	1.02542	0.0273	0.3588		5
rs9606194	22:19936209	A/G	COMT	intron	0.987	1.01319	0.0118	0.2691		7
rs9606195	22:19937784	T/G	COMT	intron,near-gene-5	0.873	1.00130	0.0138	0.9275		6
rs9606196	22:19947389	T/G	COMT	intron	0.808	1.02245	0.0132	0.09284		2a
SNP	Position	Alelle	Gene	Annotation	Info	Or	Se	P-value	eQTL	Score^*

Note: RegulomeDB score^*

score	supporting data	score	supporting data
1a	eQTL + TF binding + matched TF motif + matched DNase Footprint + DNase peak	6	other
2a	TF binding + matched TF motif + matched DNase Footprint + DNase peak	5	TF binding or DNase peak
1b	eQTL + TF binding + any motif + DNase Footprint + DNase peak	4	TF binding + DNase peak
2b	TF binding + any motif + DNase Footprint + DNase peak	3b	TF binding + matched TF motif
1c	eQTL + TF binding + matched TF motif + DNase peak	1f	eQTL + TF binding / DNase peak
2c	TF binding + matched TF motif + DNase peak	3a	TF binding + any motif + DNase peak
1d	eQTL + TF binding + any motif + DNase peak	1e	eQTL + TF binding + matched TF motif

CNV Information

Reference	Study type	Sample size
18668038	GWAS	3391 cases; 3181 controls
18511947	GWAS	359 cases; 718 controls
20489179	GWAS	977 cases; 2000 controls
21489405	GWAS	834 cases; 672 controls
19181681	GWAS	471 cases; 2792 controls
Reference	Study type	Sample size

eQTL Information